Investigating tumor perfusion by hyperpolarized (thirteen) C MRI with comparison to traditional gadolinium contrast-enhanced MRI and pathology in orthotopic human GBM xenografts.

PDF Remember to find a format to save lots of. By making use of this company, you concur that you'll only continue to keep content for personal use, and will not likely openly distribute them by using Dropbox, Google Travel or other file sharing services Be sure to affirm that you simply accept the terms of use. Cancel

The get bandwidth e.g. of Yb:KGW and Yb:KYW is incredibly huge compared with that of Yb:YAG. This permits for large wavelength tunability and for Considerably shorter pulse durations from mode-locked lasers. Values very well under 100 fs are actually obtained with passive manner locking.

In summary, we shown that undoped scintillator crystals: BGO, GGG, YSO, LSO and LYSO are economical nonlinear products for broadband SC technology from the near-infrared and shorter-wave infrared spectral ranges, when pumped by one hundred eighty fs essential harmonic pulses from an amplified Yb:KGW laser. YSO, LSO and LYSO made two octave-spanning SC spectra, which Review to SC spectra generated in YAG. These resources exhibit fairly related performances to YAG also with regards to threshold and best pump pulse energies for SC generation. Nevertheless, for what fears the likelihood to work at large laser pulse repetition amount, YSO, LSO and LYSO show sturdy Procedure only at 10 kHz and swiftly degrade (in just a few minutes) at 20 kHz. In addition to the relatively small SC technology threshold (169 nJ), GGG shown excellent effectiveness characteristics within the brief-wave infrared with the optimal pump pulse Power of 464 nJ, that is two times lower than in YAG: the most important pink-shifted spectral broadening and the very best spectral Vitality density, outperforming KGW and YAG crystals in that aspect.

The monoclinic crystal structures brings about a normal birefringence, helping to keep away from thermally induced polarization rotation and depolarization loss.

That is a preview of subscription written content, log in via an institution to check accessibility. Entry this information

Later on, we will adopt a laser seed by using a broader spectral bandwidth and utilize an acousto-optical programmable dispersive filter to modulate the seed’s spectrum to help make whole use in the acquire bandwidth of our regenerative amplifier.

KGW (potassium gadolinium tungstate) is actually a crystal that is commonly applied as being a Raman crystal in Raman spectroscopy. It is just a colorless, clear crystal that includes a significant Raman scattering performance and a powerful Raman spectrum, rendering it well suited for A variety of Raman programs.

Ask RP Photonics for virtually any assistance regarding tungstate lasers, which includes femtosecond lasers and large-ability lasers.

The two-pump laser could give as much as a hundred and twenty W electric power. Around sixty% of the get more info most pump ability was applied in our experiment considering the reduced efficiency with the dichroic mirrors. Less than this dual-crystal configuration, our cavity supports a a hundred W pump electrical power input, as reviewed in Section 2.two. Higher-high quality dichroic mirrors will probably be made use of Down the road, and laser pulses will likely be stretched to an extended pulse period.

The Martinez stretcher stretched the seed pulses to ~250 ps with 1600 grooves/mm grating. The enter on the stretcher (incident angle: fifty two°) and that in the compressor incident for the grating have been in the identical facet; hence, a slight angular tuning on the grating may very well be built to get the very best compression outcome. Inside the compressor, the input angle to the grating and the space among the interpretation phase (S1) as well as transmission grating (TG) have been created to compensate to the stretcher dispersion and all dispersion introduced by the elements.

A multi-go major amplifier will even more Enhance the Electrical power to earlier mentioned 40 mJ. We're going to use cryogenically cooled Yb:KGW technologies to restrain the thermal impact. Two levels of compression will likely be applied soon after amplification. The primary stage includes a typical Treacy-variety compressor, and could compress the heartbeat period to down below three hundred fs with an effectiveness of close to 70%. The next stage entails a gas-filled multi-go cell[

Determine 8 Intra-cavity pulse amplification course of action monitored by an oscilloscope. The pulse underwent an unsaturated amplification as a result of mirror destruction limitation.

The two energies are marked via the dashed strains as well as their values are labeled within the plots. The identical characteristics ended up also noticed in KGW and YAG crystals, whose spectral broadening dynamics are revealed for a comparison in Fig. 4.